Night Owl Tincture

SKU
TIN-NIO
$22.00
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Overview

120 mL (4.06 oz)

Ingredients:

passionflower leaf*, skullcap leaf*, valerian root*, and lavender flower* extracted in 40% potato vodka (*organic)

organic ingredients

Organic

Pure organic ingredients that are completely earth-friendly.

wildcrafted herbs

Wildcrafted

Ethically wild harvested plants from their natural habitats.

Non-GMO ingredients

Non-GMO

All ingredients are non-GMO (not genetically modified).

Kosher ingredients

Kosher

Herbs are Kosher and everything is made with plant-based ingredients.

gluten-free

Gluten-Free

Ingredients do not contain gluten.

eco-friendly

Eco-Friendly

Everything is handmade. We use minimal product packaging and large quantities for less waste.

Cruelty-Free

Cruelty-Free

We do not test on animals, nor contribute to the testing of animals.

lab-tested

Lab-Tested

Our herbs are lab-tested by a third-party laboratory to maintain quality and purity.

Good Manufacturing Practices

Good Manufacturing Practices

We follow the current good manufacturing practices according to law.

The Night Owl blend of passionflower, skullcap, valerian, and lavender relieves those in the darkness of insomnia, anxiety, and depression. Because of the mode of actions of this herb blend, it works in these different ways. It involves herbs that can relax the nerves, soothe muscles, ease the mind in its heightened state, and ease bodily and psychological tension. For insomnia, this herb blend can help the whole body to transition into restful sleep and ease psychological tension without causing any next-day hangover. Insomnia can be symptomatic, meaning a symptom of an underlying problem, whether stress, anxiety, depression, or disposition at the end of the day. Night Owl can be taken before intended sleep or in the night. For stress, nervous debility, anxiety, and depression, the herb blend can ease the mind in its heightened state, stabilize blood pressure, ease muscular tension, and enhance nerve function. In this way, this herb blend can be taken when nervous debility builds, overthinking, ruminating, and any heightened state, or it can be therapeutically used daily before intended sleep or at a specific time of day when the condition is more often debilitating.

In times of insomnia, chronic stress, anxiety, depression, and any chronic condition, herbal therapy involves other healthy lifestyle habits to correct the condition – habits, like eating a variety of whole foods (and foods for the soul), keeping a good circadian rhythm and sleeping adequately, drinking plenty of water, exercising regularly, having sunshine and fresh air, maybe listening to music, having a creative outlet, establishing a routine of herb use for needed support, and other personalized healthy habits. These personal needs should be met because they promote healthfulness, prepare the body to cope in times of illness, support the body’s ability to heal and strengthen, and can help many underlying causes of insomnia, nervous debility, anxiety, and depression.

Suggested Use

Gently swirl tincture, then fill dropper. A full dropper will seemingly fill halfway, however this signifies a full dropper, measuring 1 mL, which is about 20 to 25 drops. Administer directly under the tongue, dilute in a small amount of water or fruit juice, mix with maple or blackstrap molasses to create a medicinal syrup, or add to a cup of herbal tea for a more powerful herbal remedy. To preserve the quality of your tincture, avoid touching the dropper to your mouth when administering. Empty dropper and securely close bottle after each use. Store in a cool, dry, dark location. Tinctures have a stable shelf life and will last for years.

Take orally:

Take when nervous debility builds, overthinking, ruminating, and any nervous, restless, and heightened state. Take therapeutically daily before intended sleep or at a specific time of day when the condition is more often debilitating. Take 1-6 mL per day, as needed. For children under 12 years but older than 2 years, take 1⁄2-2 mL per day, as needed.

Supplement Facts

Dosage: 1 mL (120 doses per bottle)
Daily Limit: 2-6 mL

Amount per dosage
Passionflower leaf 87.5 mg
Skullcap leaf 62.5 mg
Valerian root 55 mg
Lavender flower 45 mg

The recommended dose varies based on condition, sensitivity, body chemistry, and body weight. Each person will need to experiment to discover what dose works best with a specific tincture. Tinctures are used as needed. This recognizes that each person finds their constitution and condition in varying degrees, and possibly varying times of day. If you have never used the tincture before, it is best to initially take only about 1/4 to 1/2 the recommended dosage, slowly increasing the dosage as needed with each use determining what dosage is best and when.

Safety Considerations

  • ♡ This is NOT recommended for anyone under the age of 2 years. Careful consideration should be given when administering herbs to children under the age of 12 years. Chamomile is useful for children who are little night owls.
  • ♡ If you have never used the tincture before, it is recommended to only take a small amount to ensure no allergic reaction occurs. Each product description includes a complete list of ingredients. People with sensitivities to any listed ingredient should not use the product.
  • ♡ Herbs are powerful. If you are pregnant, nursing, or on any medications, it is recommended to consult with a health care practitioner before using herbs internally.
  • ♡ These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Passionflower

Passiflora incarnata

Passifloraceae
leaf
Illustration of Passionflower by Joseph Franz Jacquin, E. Fenzl, and I. Schreibers
Illustration of Passionflower by Joseph Franz Jacquin, E. Fenzl, and I. Schreibers from Eclogae plantarum rariorum aut minus cognitarum Vol. 1 (1811) and Vol. 2 (1844)

Botany. Passionflower is a woody, hairy, climbing vine native from southern United States, Virginia and Florida westward to Missouri and Texas, to Guatemala. It has a perennial root growing herbaceous shoots with three-lobed, finely serrated leaves and climbing by means of axillary tendrils. Solitary, axillary pale or yellowish sweet-scented flowers tinged with a pinkish purple calyx crown bloom from May to July. The ripe berry, named passionfruit, is the size of a small apple and has sweet yellow pulp with many seeds.

History. It is named from the supposed resemblance of the crown of thorns in the corona filament in the center of the blossoms representing the Passion of Jesus Christ, as well as other flower parts including 3 stigmas for 3 nails, 5 anthers for 5 wounds, and the white and blue colors representing purity and heaven. Passionflower is an old traditional remedy for the nervous system, insomnia, tension, spams, and restlessness.

Constituents. Passionflower contains many alkaloids (harmine, harman, harmol, harmaline, harmalol, passaflorine) and flavonoids (apigenin, homoorientin, isovitexin, kaempferol, luteolin, orientin, quercetin, rutin, saponaretin, saponarin, vitexen, chrysin).

Qualities. It is sweet and useful for irritated or constricted states that would respond well to relaxation.

Actions. The herb showing various , , , pain-relieving (), anti-anxiety (), and effects.

Our passionflower leaf, Passiflora incarnata, is organic, non-GMO, and Kosher. Passionflower has many synergistic actions that contribute to calming and relaxing qualities that can be beneficial during times of great stress, nervousness, anxiety, irritability, and insomnia.

"At midnight, in the month of June,
I stand beneath the mystic moon."
– Edgar Allan Poe, The Sleeper (1831), lines 1-2

Passionflower has a sedative effect on the central nervous system and acts as a hypotensive, lowering blood pressure and preventing abnormal rapid heart rate (tachycardia). Many of the alkaloids and flavonoids act together to create this hypnotic and sedative action. The compounds themselves do not create the effect but only when they are combined, meaning the whole herb’s activity is important for the efficiency of the herb’s actions. This hypnotic and sedative effect has been firmly established by several studies. The effect was first experimentally verified in 1920 with the researcher noting that "unlike what happens with narcotics, sleep was induced normally with easy, light breathing, with little or no neural or mental depression. Upon awakening the patients showed no signs of confusion or stupor or melancholy." The herb can induce relaxation and sleep, relieve insomnia, and ease the transition into restful sleep without causing any next-day hangover.

Many of the flavonoids, including apigenin, include relaxing antispasmodic, pain-relieving, and anti-inflammatory effects that can be helpful in discomfort, restlessness, restless legs, bodily tension, muscle spasms, twitching, and muscle soreness and fatigue. It can assist with asthma that is associated with spasmodic activity and state of tension. Apigenin is also in Chamomile. Passionflower can be supportive for nerve pain, such as neuralgia, and the viral infection of nerves called shingles. The tranquilizing hypnotic actions make this herb helpful for nervousness, restlessness, stress, and psychological tension.

Passionflower has been shown to have an anti-anxiety (anxiolytic) effect, however, there are only a few clinical trials available using only this herb to support its use for anxiety, which is only suggestive of its effectiveness. There are a few trials with its use for anxiety in relation to a blend of other herbs, including valerian, which is included in the Night Owl blend, but they’re not enough to establish passionflower as an anxiolytic. Also some studies include only a small number of participants, which isn’t enough to establish it: One study showed 63 patients with an initial 90 mg dosage of passionflower was effective to treat anxiety, tenseness, and irritation. Another study of 36 patients with general anxiety showed that a daily dosage of 45 drops of the herb's extract over a 28-day period was effective. The compounds responsible for the sedative and anxiolytic activity are not fully understood but the majority of published research suggest the flavonoids are related to this function, being an agonist neurotransmitter of benzodiazepine cell receptors, which is similar to Skullcap and Valerian. The Night Owl blend, with its sedative, hypnotic, relaxing qualities, give the potential to accentuate this herb's anxiolytic activity that might one day be scientifically well-established.

The mechanism of action is probably related to the modulation of the γ-aminobutyric acid (GABA) system. Passionflower enhances the effect of the neurotransmitter called gamma-aminobutyric acid (GABA). A neurotransmitter is a messenger that sends information between nerve cells (neurons) and other cells in the body through a synapse. These messengers can act in predictable ways but also be affected by medications, disease, and other messengers. Neurotransmitters communicate in 3 ways: excitatory, inhibitory, or modulatory. Excitatory neurotransmitters have excitatory effects on the neuron and the likelihood that the neuron will fire an action potential is increased. Generally, when you are aroused, ready for action, your body produces excitatory chemicals, such as epinephrine (adrenaline), glutamate, histamine, and dopamine, to stimulate muscles, increase heart rate, and allow your body to take action. Inhibitory neurotransmitters have inhibitory effects on the neuron and the likelihood that the neuron will fire an action is decreased. During rest and relaxation, your body produces inhibitory chemicals, such as GABA and serotonin, to allow your body to rest, digest food, sleep, recover from stress and injury, and heal. Modulatory neurotransmitters can affect a number of neurons at the same time and influence the effects of other chemical messengers. The system works in opposition at times and complements each other in other times. If you stay in a prolonged state of arousal, the constant presence of excitatory chemicals (including adrenaline) can do damage in the body, such as hypertension, ulcers, headaches, and insomnia. It is crucial for normal brain function for the balance between excitatory and inhibitory nerves. Events and triggers of depression, anxiety, insomnia, and other disorders in the central nervous system can affect the balance between chemical excitation and inhibition. In many nervous disorders, the active excitability of the local nerve circuits is altered, meaning there may be an unbalance of synaptic excitation, inhibition, or both. The unbalance of excitation or inhibition result in altered excitability and impaired nerve processing of incoming information. The balance means that the excitation and inhibition nerve cells are at the right concentrations, in the right places, and at the right time. Gamma-aminobutyric acid (GABA) is an amino acid that serves as a primary inhibitory neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. Being an inhibitory neurotransmitter, the GABA receptor calms nerves and is the body’s natural relaxation receptors that are produced by the brain to promote sleep, pain-relief, and relaxation. The body forms GABA from glutamate, although their roles are opposite in the nervous system, as glutamate is considered an excitatory neurotransmitter and GABA an inhibitory neurotransmitter. The imbalance of these neurotransmitters play a role in various pathways of disease. Various neurological and psychiatric diseases and conditions have been associated with low levels of GABA, including generalized anxiety, schizophrenia, autism spectrum disorder, major depressive disorder, seizures, and epilepsy. GABA binds to two major receptors, the GABAA and GABAB receptors. The receptors are also referred to as benzodiazepine receptors. Nervine herbs (and drugs) that act on nerve receptors can be agonists, modulators, or antagonists. Agonist herb compounds occupy receptors and activate them. Antagonist herb compounds occupy receptors but do not activate them and block receptor activation by other agonists. Modulator herb compounds balances and adjusts, modifying the message as needed. Many sedative herbs, as well as anxiety medications, antidepressants, or benzodiazepines, work similarly by interacting with and activating the GABA receptor. It is important that although GABA concentrations may be altered in these types of conditions and states of mind, treatment using GABAA receptor agonists are not the only treatment and therapy, however, it may benefit in times of need, like during times of anxiety, before sleep, and before anticipated stress, such as a speech or presentation. Passionflower enhances the effect of GABA binding to the GABAA receptor, resulting in sedative, anti-anxiety, hypnotic, and muscle relaxant properties. Specifically, the flavonoids, including apigenin and chrysin, and the harman alkaloids bind to the receptor and exhibit the anxiolytic activity. The flavonoids are partial agonists of GABAA receptors and inhibit the uptake of [3H]-GABA exhibiting anxiolytic activity.

Skullcap

Scutellaria lateriflora

Lamiaceae
leaf
Illustration of Skullcap by Charles F. Millspaugh, M.D., American Medicinal Plants (1887)
Illustration of Skullcap by Charles F. Millspaugh, M.D., American Medicinal Plants Vol. 1 and 2 (1887)

Botany. Skullcap is a North American perennial plant. It has a fibrous yellow rootstock producing a branching stem 1 to 3 feet high with opposite, ovate, serrate leaves, and the axillary two-lipped flower is pale purple or blue that blooms from July to September.

History. Skullcap has been used for convulsions, hysteria, and irritability of the nervous system. It was used as a female remedy for treatment of dysmenorrhea, menorrhagia, and other female disorders.

Constituents. The compounds consist of volatile oils (namely scutellarin), flavonoids (baicalein, baicalin, scutellarin, chrysin, and wogonin), iridoids (including catalpol), and tannins.

Qualities. Skullcap is a bitter herb with sedative properties, good for over-thinkers and tension of any kind, mind or body.

Actions. The herb a with , , , , and muscle relaxant properties.

Our skullcap, Scutellaria lateriflora, are organic, non-GMO, and Kosher. Skullcap is a mild sedative, relaxant, and powerful nervine that effectively soothes nervous tension while rejuvenating the central nervous system. The nervine qualities act in multiple ways throughout the body. Skullcap can ease the body and mind and useful for symptoms of muscle cramps and spams, muscular tension, headache, stress, irritability, nervous tension, premenstrual syndrome (PMS), menstruation, menopause, insomnia, anxiety, and depression.

"It soothes and quiets the irritability of the nervous system, giving tone and regularity of action, lessens cerebral excitement, abates delirium, diminishes febrile excitement, excites diaphoresis and diursis, and accomplishes its work without any subsequent unpleasant reactions."
– Grover Coe, M.D., Concentrated Organic Medicines (1862), page 345

Skullcap is a powerful sedative that can calm that body. Skullcap's calming nervine properties are partly due to the volatile oil, scutellarin, and the flavonoid, chrysin. These properties result from the herb’s effect on nerve function and balance in the brain. Clinical trial has also demonstrated that the herb is anti-anxiety (anxiolytic) due to the flavonoid interactions with the neurotransmitter called gamma-aminobutyric acid (GABA). A neurotransmitter is a messenger that sends information between nerve cells (neurons) and other cells in the body through a synapse. These messengers can act in predictable ways but also be affected by medications, disease, and other messengers. Neurotransmitters communicate in 3 ways: excitatory, inhibitory, or modulatory. Excitatory neurotransmitters have excitatory effects on the neuron and the likelihood that the neuron will fire an action potential is increased. Generally, when you are aroused, ready for action, your body produces excitatory chemicals, such as epinephrine (adrenaline), glutamate, histamine, and dopamine, to stimulate muscles, increase heart rate, and allow your body to take action. Inhibitory neurotransmitters have inhibitory effects on the neuron and the likelihood that the neuron will fire an action is decreased. During rest and relaxation, your body produces inhibitory chemicals, such as GABA and serotonin, to allow your body to rest, digest food, sleep, recover from stress and injury, and heal. Modulatory neurotransmitters can affect a number of neurons at the same time and influence the effects of other chemical messengers. The system works in opposition at times and complements each other in other times. If you stay in a prolonged state of arousal, the constant presence of excitatory chemicals (including adrenaline) can do damage in the body, such as hypertension, ulcers, headaches, and insomnia. It is crucial for normal brain function for the balance between excitatory and inhibitory nerves. Events and triggers of depression, anxiety, insomnia, and other disorders in the central nervous system can affect the balance between chemical excitation and inhibition. In many nervous disorders, the active excitability of the local nerve circuits is altered, meaning there may be an unbalance of synaptic excitation, inhibition, or both. The unbalance of excitation or inhibition result in altered excitability and impaired nerve processing of incoming information. The balance means that the excitation and inhibition nerve cells are at the right concentrations, in the right places, and at the right time. Gamma-aminobutyric acid (GABA) is an amino acid that serves as a primary inhibitory neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. Being an inhibitory neurotransmitter, the GABA receptor calms nerves and is the body’s natural relaxation receptors that are produced by the brain to promote sleep, pain-relief, and relaxation. The body forms GABA from glutamate, although their roles are opposite in the nervous system, as glutamate is considered an excitatory neurotransmitter and GABA an inhibitory neurotransmitter. The imbalance of these neurotransmitters play a role in various pathways of disease. Various neurological and psychiatric diseases and conditions have been associated with low levels of GABA, including generalized anxiety, schizophrenia, autism spectrum disorder, major depressive disorder, seizures, and epilepsy. GABA binds to two major receptors, the GABAA and GABAB receptors. The receptors are also referred to as benzodiazepine receptors. Nervine herbs (and drugs) that act on nerve receptors can be agonists, modulators, or antagonists. Agonist herb compounds occupy receptors and activate them. Antagonist herb compounds occupy receptors but do not activate them and block receptor activation by other agonists. Modulator herb compounds balances and adjusts, modifying the message as needed. Many sedative herbs, as well as anxiety medications, antidepressants, or benzodiazepines, work similarly by interacting with the GABA receptor. It is important that although GABA concentrations may be altered in these types of conditions and states of mind, treatment using GABAA receptor agonists are not the only treatment and therapy, however, it may benefit in times of need, like during times of anxiety, before sleep, and before anticipated stress, such as a speech or presentation. Skullcap enhances the effect of GABA at the GABAA receptor, resulting in sedative, anti-anxiety, hypnotic, and muscle relaxant properties. Research has shown that the flavonoid, baicalin, can produce neuroprotective effects and can protect nerve cells from damage in conditions of stress. The flavonoid, chrysin, gives anxiolytic (anti-anxiety) actions being an agonist of the benzodiazepine GABA receptors. Many anxiety and depression medications work similarly to Skullcap by interacting with the GABA (benzodiazepine) receptor, often referred to as "benzodiazepines." Herbal therapy for anxiety and depression involves a balance in all aspects of whole health, and skullcap can be incorporated in the treatment for anxiety and depression.

Skullcap can boost mood. It can stimulate the release of endorphins, relieve tension, and generally balances mood. Skullcap has been associated with increased activity in the liver significantly boosting the efficiency of the liver reducing toxin levels in the body and blood, thereby improving overall health and wellness. Skullcap can help mental alertness by removing the nervous tension that often interferes with learning, recall, logical thinking, and memory formation. Through strong hypotensive action, skullcap stabilizes and normalizes blood pressure, which can help muscular and nervous tension. It relaxes muscles, cramps, twitching, and spasms. Skullcap has anti-inflammatory effects. The flavonoids have been shown to reduce inflammation in the body by binding and interrupting chemokines, which are critical proteins secreted by cells during inflammation and infection. During headache and migraine, it can help calm the body, relieve muscular tension, ease throbbing, and painful aura. Skullcap is helpful for irritability, stress, anxiety, depression, hysteria, nervous excitability, agitation, restlessness, neuralgia, and other nervous ailments. It can ease premenstrual tension and relax muscles during menstruation. Skullcap is a good remedy for inducing sleep and helping insomnia and sleep disorders, while helping some of its underlying causes. The ability to ease physical symptoms as well as underlying psychological tension is one of the greatest benefits of herbs in stress, anxiety, headaches, pain, and depression.

Valerian

Valeriana officinalis

Caprifoliaceae
root
Chromolithograph of Valerian by Walther Otto Müller, C. F. Schmidt, and K. Gunther
Chromolithograph of Valerian by Walther Otto Müller, C. F. Schmidt, and K. Gunther from Köhler's Medizinal-Pflanzen Vol. 1 (1887), Vol. 2 (1890), and Vol. 3 (1898)

Botany. Valerian is native to Europe and is in the Caprifoliaceae plant family, also known as the honeysuckle family. The roots are short and conical with one stem arising from the root reaching 3 to 4 feet, terminating in 2 or more pairs of flowering stems.

History. Valerian has a far past with its therapeutic uses being described by the ancient Greek physician, Hippocrates of Kos (b. 460 BC). It has been extolled by other Greek physicians, Pedanius Dioscorides of Anazarbus (AD 40-90) and Galen (AD 129-216), as an aromatic and diuretic. Valerian root's traditional herb use was to calm upset nerves, treat psychological disorders, relieve insomnia, manage pain, and ease headache.

Constituents. Valerian contains more than 150 phytochemicals with different physiological activity. In 1966, many of its active compounds were finally identified and studied to scientifically confirm its traditional use: volatile oil (mainly composed of sesquiterpenes such as bornyl acetate, β-caryophyllene, valerone, and valerenic acid), bicyclic iridoids known as valepotriates (including valtrate, isovaltrate, acetoxy-valerenic acid, isvaleroxy-hydoxydidrovaltrate), and baldrinals.

Qualities. Valerian is strong, bitter, and earthy, useful in constricted and tense states.

Actions. The root is a beautiful herb with , , , , neurotrophic (increases BDNF expression), anti-aggressive, antianxiety (), and actions.

Our valerian root, Valeriana officinalis, is organic, non-GMO, and Kosher. It is helpful for overexcitement, nervousness, and sleeplessness and to relax the body and mind.

Valerian is a powerful nervine herb with action. Several of valerian's compounds contribute to the nervine and effect, and there is no main active compound, meaning the compounds of the whole herb work together synergistically to create the whole effect. The volatile oil, valerenic acid and its derivatives, have sedative properties. The valepotriate compounds in valerian have sedative, muscle relaxant, anticonvulsive, hypotensive, tranquilizing, neurotrophic, and anti-aggressive properties. These properties result from the herb’s effect on nerve function and balance in the brain. This herb is shown to increase the amount of the neurotransmitter, called gamma-aminobutyric acid (GABA), in the nervous system. A neurotransmitter is a messenger that sends information between nerve cells (neurons) and other cells in the body through a synapse. These messengers can act in predictable ways but also be affected by medications, disease, and other messengers. Neurotransmitters communicate in 3 ways: excitatory, inhibitory, or modulatory. Excitatory neurotransmitters have excitatory effects on the neuron and the likelihood that the neuron will fire an action potential is increased. Generally, when you are aroused, ready for action, your body produces excitatory chemicals, such as epinephrine (adrenaline), glutamate, histamine, and dopamine, to stimulate muscles, increase heart rate, and allow your body to take action. Inhibitory neurotransmitters have inhibitory effects on the neuron and the likelihood that the neuron will fire an action is decreased. During rest and relaxation, your body produces inhibitory chemicals, such as GABA and serotonin, to allow your body to rest, digest food, sleep, recover from stress and injury, and heal. Modulatory neurotransmitters can affect a number of neurons at the same time and influence the effects of other chemical messengers. The system works in opposition at times and complements each other in other times. If you stay in a prolonged state of arousal, the constant presence of excitatory chemicals (including adrenaline) can do damage in the body, such as hypertension, ulcers, headaches, and insomnia. It is crucial for normal brain function for the balance between excitatory and inhibitory nerves. Events and triggers of depression, anxiety, insomnia, and other disorders in the central nervous system can affect the balance between chemical excitation and inhibition. In many nervous disorders, the active excitability of the local nerve circuits is altered, meaning there may be an unbalance of synaptic excitation, inhibition, or both. The unbalance of excitation or inhibition result in altered excitability and impaired nerve processing of incoming information. The balance means that the excitation and inhibition nerve cells are at the right concentrations, in the right places, and at the right time. Gamma-aminobutyric acid (GABA) is an amino acid that serves as a primary inhibitory neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. Being an inhibitory neurotransmitter, the GABA receptor calms nerves and is the body’s natural relaxation receptors that are produced by the brain to promote sleep, pain-relief, and relaxation. The body forms GABA from glutamate, although their roles are opposite in the nervous system, as glutamate is considered an excitatory neurotransmitter and GABA an inhibitory neurotransmitter. The imbalance of these neurotransmitters play a role in various pathways of disease. Various neurological and psychiatric diseases and conditions have been associated with low levels of GABA, including generalized anxiety, schizophrenia, autism spectrum disorder, major depressive disorder, seizures, and epilepsy. GABA binds to two major receptors, the GABAA and GABAB receptors. The receptors are also referred to as benzodiazepine receptors. Nervine herbs (and drugs) that act on nerve receptors can be agonists, modulators, or antagonists. Agonist herb compounds occupy receptors and activate them. Antagonist herb compounds occupy receptors but do not activate them and block receptor activation by other agonists. Modulator herb compounds balances and adjusts, modifying the message as needed. Many sedative herbs, as well as anxiety medications, antidepressants, or benzodiazepines, work similarly by interacting with the GABA receptor. The compounds of valerian, including valerenic acid, serve as GABA agonists, and the effect of the plant on GABAA receptors is similar to the effect of benzodiazepines. The herb enhances the effect of GABA at the GABAA receptor, resulting in sedative, anti-anxiety, hypnotic, and muscle relaxant properties. The root works by causing GABA to be released from brain nerve endings, blocking GABA from being taken back to nerve cells, and inhibiting an enzyme that destroys GABA. Antidepressant and mood-stabilizing effects have also been proposed for valerian, which could be due to the herb's ability to interfere with noradrenergic and dopaminergic neurotransmitters, especially serotonin and GABA. It is important that although GABA concentrations may be altered in these types of conditions and states of mind, treatment using GABAA receptor agonists are not the only treatment and therapy, however, it may benefit in times of need, like during times of anxiety, depression, before sleep, and before anticipated stress, such as a speech or presentation.

Research shows valerian functions to suppress and regulate the , relieve tension and restlessness, help regulate , and regulate mental illness and distress. It has been shown to help with hypertension and revealed to have a tranquilizing effect. It is an effective muscle relaxant. With these actions, valerian is helpful for stress, anxiety, nervous tension, shaking and trembling, restlessness, sleeplessness, panic, insomnia, and bodily tension symptoms, including headaches, migraines, muscle cramps, and an erroneous disposition. A useful herb sleep aid, valerian promotes normal sleep and relieves exhaustion and insomnia, without suppressing necessary REM phases. In a randomized, double-blind, placebo-controlled, crossover clinical trial that was conducted on 39 patients undergoing hemodialysis, valerian was shown to significantly improve sleep quality, the symptoms of state anxiety, and depression.

Valerian is shown to improve coordination, enhance concentration, and boost energy. Many of valerian’s compounds increase brain-derived neurotrophic factor (BDNF) expression, which has an antidepressant effect. BDNF plays an important role in nerve survival and growth and contributes to nerve plasticity, which is the capacity of the nervous system to modify itself, functionally and structurally, in response to an incident, experience, or injury. BDNF also regulates glucose and energy metabolism and prevents exhaustion of beta-cells that produce insulin, which is a hormone that controls the level of glucose in the blood. Decreased levels of BDNF are associated depression and with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. There have been several studies showing the improvement of behavioral disturbances and disorders, such as hyperactivity and irritability, with an increase in BDNF expression. By keeping BDNF at a healthy balance, the nervous system can function at an optimal level transferring information between nerves and their targets, and potential physical and mental illnesses are prevented. Valerian root extract is shown to increase the expression of BDNF levels in SH-SY5Y cells, and the compound valerenic acid is crucial for the neuronal activity. Many anxiety and depression medications work similarly to Valerian by interacting with the GABA receptor and increasing BDNF expression. Exercise can also increase BDNF expression. Herbal therapy for anxiety and depression involves a balance in all aspects of whole health, and valerian can be incorporated in the treatment for anxiety and depression.

Safety Considerations. Valerian can exaggerate drugs that cause drowsiness and muscle relaxation. Valerian should not be used with ketamine, esketamine, buprenorphine, and sodium oxybate because of increased side effects, such as drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination.

Lavender

Lavandula angustifolia

Lamiaceae
flower
Chromolithograph of Lavender by Walther Otto Müller, C. F. Schmidt, and K. Gunther
Chromolithograph of Lavender by Walther Otto Müller, C. F. Schmidt, and K. Gunther from Köhler's Medizinal-Pflanzen Vol. 1 (1887), Vol. 2 (1890), and Vol. 3 (1898)

Botany. Lavender is a perennial mint Mediterranean plant cultivated for its aromatic flowers. The square stems grow 1 to 2 feet high are gray-green with flaking bark. The gray-green leaves are opposite, sessile, downy, and lanceolate to oblong-linear, and the lilac-colored tubular flowers are arranged in successive whorls up the stem blooming in July to September.

History. Lavender is native to the western Mediterranean. The herb has been long used, with record of the Greek physicians, Dioscorides (AD 40-90) and Galen (AD 129-216), and Arabic physicians appreciating the valuable benefits of the plant.

Constituents. The of this beautiful herb consist of a high content of volatile oils: (linalyl acetate, linalol, lavandulyl acetate, borneol, limonene); coumarins: (umbelliferone and coumarin); triterpenes; and flavonoids.

Qualities. Lavender is highly aromatic and oily, useful in distressed and tense states.

Actions. The herb is highly and has , , , , and properties.

Our highly aromatic lavender flowers, Lavandula angustifolia, are organic, non-GMO, and Kosher. Mints are typically relaxing on the nervous system and lavender is highly regarded for nervousness, muscle tension, headaches, muscle spasms and cramping, and psychological tension. Because of the high volatile oil content in mints, lavender is stimulating but cooling and relaxing. The effects of these compounds include , , relaxing nervine, antidepressant, and hypotensive. The herb can allay restlessness, ease muscular pain, and allow the body to calm. The antispasmodic activity of lavender is particularly helpful in times of restlessness, nervous debility, muscle spasms, and the aches and pains of rheumatism. Because of the high volatile content, lavender has a powerful aroma that is quite significant that gives a soothing action relieving flatulence and gas, as well as soothing the lining and muscle of the digestive tract. This soothing effect can be accentuated when nervousness, distress, and anxiety affect the digestive system. Lavender has a relaxing nervine effect, promoting sleep and calming the mind and body, and the herb has also been shown to have an uplifting and anti-depressant effect, specifically in combination with other therapies. The aroma and nervine effects can relax and relieve headaches, particularly when nervous or stress-related.

Potato Vodka

40% alcohol by volume

Idaho Russet Burbank potato

Our vodka is 100% potato-distilled, grain-free, gluten-free, sugar-free, and carbohydrate-free. It contains no additives, citric acids, or glyceride. Our vodka is American-handcrafted in Idaho using non-GMO Idaho Russet Burbank potatoes and water from natural well sources near the Grand Teton Mountains. Vodka is created through fermentation when alcohol is formed, then distillation, dilution, and filtration to purify vodka, remove any unwanted elements and excess water, and increase the alcohol by volume content. It is distilled in a four-column apparatus to control the removal of impurities and filtered 5 times for extreme clarification. Our vodka is a clean pure neutral spirit that highlights the aromas, flavors, and bitters of herbs.

Our tinctures are made using traditional practice methods of tincture-concocting with regard to maximum herbal potency and bioavailability of the herb's nutrients being absorbed within the body. Tinctures are crafted at room temperature through the timely method known as maceration. It is the soaking and softening of herbs at which time the equilibrium of the herbal potency is reached inside and outside the herb within the alcohol. The medium, called solvent or menstruum, for extraction of herbs depend upon the herb's solubility in that solvent. Alcohol, as the solvent, can extract herbs well and produce a potent herbal extract. It can extract both fat/oil soluble (non-polar) and water soluble (polar) herbal constituents. It can soften harder materials like roots and extract a broad range of , including those that aren’t water-soluble, like volatile oils, terpenes, alkaloids, and resins, while water (tea) is narrowed toward only water-soluble compounds. Alcohol is a wonderful carrier of herbs, being absorbed quickly through the bloodstream into the body. The body does not need to break down a liquid extract (tincture or tea), all the herbal compounds are already extracted, allowing them to be readily and quickly absorbed into the system. The alcohol in tinctures preserves herbs preventing the breakdown and loss of beneficial herbal properties. Because the tincture is a potent concentrated herbal, the amount of alcohol in a dose is extremely small (0.38 g alcohol), making tinctures completely safe – the equivalency to eating a ripe banana (up to 0.50 g of alcohol) or fermented foods (rolls 1.2 g of alcohol per 100 g) or drinking orange or grape juice. It can always be added to a hot cup of water or herbal tea to evaporate most of the alcohol, if desired.

Florida does not recognize herbal tinctures as alcoholic beverages. The state's law defines alcoholic beverages to exclude products that are "unfit for beverage purposes," and tinctures generally are not suitable for beverage use and are recognized as exempt from the jurisdiction of the Florida Division of Alcoholic Beverages and Tobacco (ABT).

Repurpose

ALL packaging and shipping materials can be repurposed and reused.

Recycle

ALL packaging and shipping materials can be recycled after use.

Compost

Tea bags and brewed-out herbs can be composted. Bags compost in 12 months.

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